Sildenafil
| Sildenafil | |
|---|---|
 | |
| Molecule | C22H30N6O4S |
| Compound | Sildenafil |
| Era | Modern |
| Origin | UK |
| Archetype | Chicago Detroit |
| Ancestor | Gabon |
| Swag Score | 1 |
| Date Added | 2025-01-12 |
[view source]Effects & Properties
Effects: Increased cGMP levels, smooth muscle relaxation, enhanced bloodflow. In ED, it facilitates penile erection by improving blood flow in response to sexual stimulation. In PAH, it reduces pulmonary artery pressure by relaxing blood vessels in the lungs.
Natural Occurrence: Sildenafil does not occur naturally. It was developed by Pfizer through chemical synthesis.
[view source]History
Sildenafil was originally developed by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett in the UK during the late 1980s as a treatment for hypertension and angina. During clinical trials, researchers noticed a remarkable side effect of sustained penile erections, leading to its repurposing. Marketed as Viagra and approved by the FDA in March 1998, it became one of the fastest-selling pharmaceutical products in history and fundamentally changed the treatment of erectile dysfunction worldwide.
[view source]Connections
Archetype: Chicago Detroit
Ancestor: Gabon
Tarot Card: Seven of Cups
Paired With: Yohimbe
[view source]Sources
- https://www.chemspider.com/Chemical-Structure.5023.html
- https://www.drugs.com/monograph/sildenafil-erectile-dysfunction.html
- Sildenafil - Wikipedia
- Sildenafil (C22H30N6O4S) - PubChem
- Sildenafil - StatPearls (NCBI)
- FDA Approves Viagra, March 27, 1998 - HISTORY
- Made Up in Britain: Viagra (Bell, Brown and Terrett 1991)