Estrogen
| Estrogen | |
|---|---|
 | |
| Molecule | C18H24O2 |
| Compound | Estradiol |
| Era | Modern |
| Origin | USA |
| Archetype | Milady |
| Ancestor | Thai |
| Swag Score | 3 |
| Date Added | 2025-01-12 |
[view source]Effects & Properties
Effects: Promotes female secondary sexual characteristics, regulates the menstrual cycle, and supports pregnancy. Increases fat storage, promotes skin hydration, and may cause breast tenderness or fluid retention.
Natural Occurrence: In humans and animals it is synthesized in the ovaries (women) and testes (men), and adrenal glands from cholesterol via enzymes like aromatase. Appearance: Estrogen is not visible in the body, existing in trace amounts in blood and tissues.
[view source]History
Estrogen was first identified in the late 1920s by biochemists Edward Doisy and Edgar Allen, who isolated estriol from the urine of pregnant women in 1929. Premarin (conjugated estrogens derived from pregnant mare urine) became commercially available in 1941 and was the most prescribed drug in America by the 1990s, primarily for menopausal hormone replacement therapy. Synthetic estrogens also became the foundation of the oral contraceptive pill approved in 1960, one of the most socially transformative pharmaceutical developments in history, and estrogen therapy remains central to transgender medicine and women's healthcare.
[view source]Connections
Archetype: Milady
Ancestor: Thai
Tarot Card: The Empress
PubChem: Estradiol
Paired With: Kwao Krua
[view source]Sources
- https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol
- https://www.drugs.com/answers/support-group/estrogen/questions/
- https://www.drugs.com/estradiol.html
- Estrogen - Wikipedia
- Conjugated estrogens - Wikipedia
- Combined oral contraceptive pill - Wikipedia
- The Discovery of Estrone, Estriol, and Estradiol and the Biochemical Study of Reproduction (JBC)
- Edgar Allen and Edward A. Doisy's Extraction of Estrogen from Ovarian Follicles (Embryo Project Encyclopedia)